Classically, the screws on the pickups face "out", so the bridge pickup would have the screws closest to the bridge, and the neck pickup would have the screws closest to the fingerboard. I have Yasuhiko Iwanade's classic book "The Beauty of the 'Burst" (a collection of Les Paul images and content spanning '58-'60), and I flipped through the whole book and couldn't find a single example where the pickups are oriented in a different direction. Unless you have a compelling reason to change it, I would stick with that orientation.
Here's a picture of a beautiful Les Paul 1959 reissue in Iced Tea Burst (I'm a real sucker for a nice Iced Tea burst) showing the classic pickup screw orientation:
